glomerulonephritis
In children, because minimal change glomerulonephritis is the most common diagnosis, initial management includes administration of high-dose corticosteroids. In older patients, and in children where this therapy is unsuccessful, a renal biopsy is requiredProteinuria usually remits on high-dose corticosteroid therapy (1 mg/kg prednisolone), some patients who respond incompletely or relapse frequently need maintenance corticosteroids, cytotoxic therapy or other agents.
MINIMAL CHANGE NEPHROPATHY AND PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS (FSGS)
Patients with minimal change nephropathy and a subgroup of patients with FSGS can be seen as opposite ends of a spectrum of conditions causing idiopathic nephrotic syndromeMinimal change disease occurs at all ages but accounts for nephrotic syndrome in most children and about one-quarter of adults. Proteinuria usually remits on high-dose corticosteroid therapy. Minimal change disease does not progress to CRF; the main problems are those of the nephrotic syndrome and complications of treatment.