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Kher
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Kher
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Over immune reaction refers to excessive, undesirable (damaging, discomfort-producing and sometimes fatal) reactions produced by the normal immune system.
Contact with allergen Sensitizing/priming dose Shocking dose
3-Allergens (antigens )these allergens can be inhalants (house dust mites), Ingestants (egg,fish, cheese), Injectants (antibiotics), Cotactants (wool, feather).
B cell
Histamine, tryptase, kininegenase, ECFA
Leukotriene-B4, C4, D4, prostaglandin D, PAF
Newly synthesized mediators
TH2
IL13
Kher
The common allergy
1-Tests that are done with patients (In vivo) Skin prick test Prick to prick test 2_tests that are done on blood (in vitro) Detection of total specific IgE Serum eosinophil cataionic protein (poor indicator in chronic asthma).
Kher
Kher
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Three distinct strategies are used to reduce the effects of allergic disease .The first strategy is that contact with allergens should be avoided.
Symptomatic treatment is achieved with antihistamines which block histamine receptors. Chromolyn sodium inhibits mast cell degranulation, probably, by inhibiting Ca influx
The third strategy is immunological (immunotherapy or desensitization) is successful in a number of allergies, particularly to insect venoms and, to some extent, pollens.
Patients are given a series of allergen injections in which the dose is initially very small and is gradually increased. This schedule of immunization can gradually convert a TH2 cell response that produces IgE into TH1 response that ceases to make IgE.