JABIR IBN HAYYAN MEDICAL UNIVERSITYCOLLEGE OF MEDICINE DEPARTMENT OF HUMAN ANATOMY
Histology of Female Reproductive SystemLecture By;
Dr. Hayder ALKifaee
6/4/2017
FEMALE REPRODUCTIVE SYSTEM
HISTOLOGYFemale Reproductive System Consists of
Paired ovariesUterine tubes
Uterus
Vagina
External Genitalia
Female Reproductive Organs
Cortex
MedullaFemale Reproductive Organs
OvaryAlmond shaped (3 x 1.5 x 1 cm)
Produce Oocytes
Produce Hormones
Coverings of Ovary
Coverings of Ovary
Menarche & Menopause
MenarcheMenopause period
Postmenopausal period
Follicular Growth & Development
Follicular Growth & Development
Beginning in Puberty with the release of FSH
Group of Primordial Follicles each month begins a process of follicular growth
Follicular Growth & Development
This involves Growth of the oocyteProliferation & changes in the Follicular cells
Proliferation & differentiation of the Stromal Fibroblasts
Primordial Follicle
Unilaminar Primary Follicle
Microvilli of Oocyte & Filopodia of Granluosa cells
Microvilli
FilopodiaGranluosa cell
Microvilli of Oocyte & Filopodia of Granluosa cells
Primordial Follicle
Unilaminar FollicleMultilayered Follicle
Primary Follicle
Multilaminar Primary Follicle
Antral Follicle
Antrum
GranulosaTheca interna & Externa
Antral Follicle
Preovulatory Follicle
Follicular Development
Graafian FollicleStages of Ovarian Follicle
Zona Pellucida
Granluosa CellUltrastructure of Primary Follicle & Zona Pellucida
Follicular Fluid
Large GAG hyaluronic acidGrowth factors
Plasminogen
Fibrinogen
Anticoagulant heparan sulfate proteoglycan
High concentrations of steroids
Wall of Antral Follicle
AntrumGranulosa
Theca I
Theca E
Stroma
Apoptosis of G. cells
Atresia of Follicle(Apoptosis & Autolysis)Hormonal Regulation of Ovarian Function
Corpus Luteum (yellowish body)
Granlosa lutein cell
Theca lutein cellCorpus LuteumGranulosa cells Granulosa lutein cells Theca interna cells Theca lutein cells
Remnants of corpus luteum are phagocytosed by macrophages, after which fibroblasts invade the area and produce a scar of dense connective tissue called a corpus albicans (L., white body).
Corpus Albicans (white body)
Uterine Tubes & Uterus
Uterine Tubes
AmpullaIsthmus
infundibulum
Intramural
Wall of the Oviduct:
MucosaMuscularis
Serosa
Cross Section in Oviduct (Ampulla)
Mucosa of the Uterine Tube Wall
Ciliated Cell& Secretory (Peg Cell)
The Epithelium Cell Types:Ciliated Cells in which ciliary movements sweep fluid toward the uterus
Secretory Peg Cells, nonciliated & often darker staining, often with an apical bulge into the lumen, which secrete glycoproteins of a nutritive mucus film that covers the epithelium
Ciliated Cell& Secretory (Peg Cell)
UTERUS Fundus, Body & Cervix
Uterine Wall Three Layers:
PerimetriumMyometrium
Endometrium
Layers of Uterine Wall
Uterus
Correlation of Ovarian &Menstrual Cycle
Arterial Supply of Endometrium
proliferative
SecretoryPremenstrual
Proliferative, Secretory& Premenstrual phasesCervix & Vagina
CervixCervical canal
Simple columnarJunction
Strat.squamous
Vagina
Exfoliative cytology of exocervix
Cervical mucosal glands
Transformation Zone(Squamo-Columnar Junction)
Epithelium
Muscular layerLamina propria
Vagina Mucosa, Muscular layer & Adventitia