Ischemic Heart Disease
Coronary ArteriesAtherosclerosis
Ischemic heart diseaseIschemic heart disease (IHD) is a condition in which there is inadequate supply of blood and oxygen to a portion of myocardium. It typically occurs when there is an imbalance between myocardial oxygen supply and demand. The most common, serious, chronic, life-theatening disease in the developed countries. The most common cause is atherosclerotic disease of an epicardial coronary artery.
Pathophysiology of myocardial ischemia
Myocardial oxigen supply is decreased Narrowed coronary arteries (sclerosis, thrombus, spasms, coronary embolism, vasculitis) Hypotension Severe anemia Myocardial oxigen demand is increased Left ventricle hypertrophy Fever Hyperthyroidism TachycardyCoronary atherosclerosis
Risk Factors: High LDL-cholesterol Low HDL-cholesterol Cigarette smoking Hypertension DiabetesThe clinical manifestations of ischemic heart disease
without clinical symptoms, sudden death. Ischemic cardiomyopathy. Angina pectoris Acut coronary syndromes
Angina pectoris
Angina pectoris means chest pain because of episodic myocardial ischemia Angina pectoris is the most common manifestation of the ischemic heart disease.Approach to the patient with angina
Hystory Location Radiation Quality Timing Factors that aggravate or relieve Associated symptomsApproach to the patient with angina
The context of the symptom development can give clues to diagnosis and management Stable exertional pectoris unstable angina acute coronary syndrome Prinzmetal’s variant anginaThe typical clinical features of angina pectoris
The typical location of pain is retrosternal. The pain can not be localized with one finger. Usually described as heaviness, pressure, squezzing. Usually associates with gradual intensification of symptoms over a period of minutes. It lasts typically 2-5 min. It can radiate to either shoulder and to both arms. It can also arise in or radiate to root of neck, jaw, teeth, and epigastrium. Exertional angina is typically relieved by rest and nitroglycerin. Associated symptoms Dyspnoe, Fatique, faintnessm Nausea, vomiting SweatingDiagnostic tests in patients with chest discomfort
ECG and X-ray are essential test for adults with chest discomfort life-threatening problems: Presence of electrocardigraphic changes consistent with ischemia or infarction: Troponin I or T PCI; percutaneous coronary intervention No evidence of life-threatening; stable angina exercise electrocradiography, stress echocardiographyECG
ECG
ECG
ECG