Dysplasia

Dysplasia : Abnormal Tissue Development

THE CHONDROOSTEODYSTROPHIES
The chondro-osteodystrophies, or skeletal dysplasias,
are a large group of disorders characterized by abnormal
cartilage and bone growth.
the conditions are presented here in clinical
rather than etiological groups, as follows:
• those with predominantly epiphyseal changes
• those with predominantly physeal and metaphyseal
changes
• those with mainly diaphyseal changes; and
• those with a mixture of abnormalities.

DYSPLASIAS WITH PREDOMINANTLYEPIPHYSEAL CHANGES

MULTIPLE EPIPHYSEAL DYSPLASIA

DYSPLASIAS WITH PREDOMINANTLYPHYSEAL AND METAPHYSEALCHANGES

HEREDITARY MULTIPLE EXOSTOSIS
(DIAPHYSEAL ACLASIS)


DYSPLASIAS WITH PREDOMINANTLYDIAPHYSEAL CHANGES
OSTEOPETROSIS
Marble bones Despite the remarkable density, the bones break easily

CONNECTIVE TISSUEDISORDERS

OSTEOGENESIS IMPERFECTA (BRITTLE
BONES)
Osteogenesis imperfecta (OI) is one of the commonest
of the genetic disorders of bone,
Abnormal synthesis and
structural defects of type I collagen result in abnormalities
of the bones, teeth, ligaments, sclerae and
skin. The defining clinical features are (1) osteopenia,
(2) liability to fracture, (3) laxity of ligaments, (4)
blue coloration of the sclerae and (5) dentinogenesis
imperfecta (‘crumbling teeth’)

Osteogenesis imperfecta (a) Moderately severe

(type IV) disease. These deformities can be corrected by
multiple osteotomies and ‘rodding’


LIMB ANOMALIES