Practical cell Injury

Practical of Cell Injury

Third Year
2018-2019




• Endometrial hyperplasia is an example of hormone-induced hyperplasia due to hyperestrogenism.

Left ventricular hypertrophy.

pathological hypertrophy due to increase demand, this results in increase in the size of the organ

On the left is a normal testis. On the right is a testis that has undergone atrophy

Metaplastic transformation (arrow) of the normal esophageal stratified squamous epithelium (Lt) to mature columnar epithelium

Squamous metaplasia of bronchial epithelium

Fatty changes of the liver a large clear space of a fat inside the hepatocyte that displaces the nucleus to the periphery

Fat Droplets

Liver cell necrosis: Nuclear changes

normal
pyknosis
karyorrhexis
karyolysis

Coagulative necrosis(infarction)-Spleen

Myocardial infraction, the cells become more eosinophilic , loss of striation, absence of nucleus & their outline are preserved

Coagulative necrosis(infarction)-kidney

Liquefactive necrosis- Brain infarction

Caseous necrosis (TB) involving hilar LN, yellow white appears as cheese-like

Caseous necrosis (Lung TB),

amorphous structureless granular eosinophilic material

Fat necrosis

shadowy outlines of necrotic fat cells, with basophilic calcium deposits, surrounded by an inflammatory reaction

Fibrinoid necrosis. It is marked by deposition of fibrin-like proteinaceous material in arterial walls, which appears eosinophilic on light microscopy.

It is a form of a necrosis of the tissue with superadded putrefaction.

Gangrenous necrosis



Dry gangrene -Ischemia
Wet gangrene –D.M



Apoptosis of an epidermal cell. The cell is reduced in size and contains brightly eosinophilic cytoplasm and a condensed nucleus.

dystrophic calcification

Fine, white granules or clumps, often felt as gritty deposits.

metastatic calcification lung