مواضيع المحاضرة: Histology practical - Endocrine System LAB-10
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Histology LAB. 10

Endocrine System
Contains of this LAB.
Thyroid gland ( MH151 )
Para -thyroid (MH15 4)
Adrenal gland (MH15 5a )
Pituitary gland (MH 149 )

Edited by F ahad A.

Mosul Medical College 2018 -2019 2th stage

Get it from

www.muhadharaty.com

This copy is used to study tissue s with Histology Guide website

to get a better result and a deeper understanding .
Do not hesitate to ask the doctors of the histology branch .

Histology

MMC 2019 – By F ahad . A.

1

1 - Thyroid gland

Capsule
Enclosed by a thin layer
of connective tissue.

صورة مكبرة

Follicles
Spherical in shape

Colloid

gel -like mass fill lumen
of each follicleهي البصيالت فقط -تحتوي
داخلها المادة الشبيهة بالجل
تسمى Colloid

Follicular Cells

C cells
"parafollicular c ells "

MMC 2019 – By F ahad . A.

2

Notes Structure

Enclosed by a thin layer of connective tissue. Capsule
connective tissue extends inwards from the capsule to partially
outline irregular lobes and lobules.
Trabeculae
spherical follicles of varying size (50 to 500 µm) in which
thyroid hormones are stored.
Follicles
lumen of each follicle is filled with the gel -like mass called
colloid. It is mostly the protein thyroglobulin (pink) and
bound thyroid hormones (triiodothyronine and
tetraiodothyronine (or thyroxin)). The clear space around
the colloid is a shrinkage artifact.
Colloid
follicles are lined by a simple cuboidal to columnar
epithelium depending on functional activity . Secrete
thyroid hormones when active.
Follicular Cell
small numbers of larger cells located at the periphery of
follicles that secrete calcitonin. They stain poorly with H&E
making identification difficult.
C - cells
"Parafollicular
cells "


Thyroid gland on histologyguide.com

151 MH VS Code – .com guide istology H

MMC 2019 – By F ahad . A.

3

2 - Parat hyroid gland

Capsule
Trabeculae

Chief Cells

Oxyphil cells Chief Cells
ذات لون احمر كثيرة السايتوبالزم
تحتوي نواة

الحظ الفرق بين النوعين من

الخاليا المتواجدة في الغدة

MMC 2019 – By F ahad . A.

4

Notes Structure

Enclosed by a thin layer of connective tissue. Capsule
Connective tissue extends inwards from the capsule to partially
outline irregular lobes and lobules.
Trabeculae
The majority of cells in the parathyroid.
-من (خاليا صغيرة 5إلى 8 مع نواة داكنة وحافة رقيقة من )ميكرومتر
السيتوبالزم الملون بخفة
They secrete parathyroid hormone ( PTH ).
Chief Cells
من (خاليا أكبر 8 إلى 21 مع نواة داكنة وسيتوبالزم قوي )بصبغة ميكرومتر
الحمراء
They appear after the first decade of life and are thought to
be non -secretory cells.
Oxyphil Cells
بالنسيج وهي كبيرة الحجم وتزداد هي الفجوات ذات اللون االبيض المتواجدة
بالحجم مع تقدم العمر
Adipose Cells
Larger cells (8 to 12 µm diameter) with dark nuclei and a
watery, clear cytoplasm.
Clear Cells

Parat hyroid gland on histologyguide.com

MH 154 VS Code – .com guide Histology

MMC 2019 – By F ahad . A.

5

3 – Adrenal gland ( MH 155a)

Cortex Medulla
تقسم منطقة ال Cotext القشرة الى ثالث
:مناطق -

وهي من الخارج للداخل

1- Zone Glomerulosa
2- Zone Fasciculata
3- Zone Reticularis

G-F-R

Capsule

توضيحة) مخطط ( صورة

Medullary Vessels

MMC 2019 – By F ahad . A.

6

Adrenal gland

Cortex

Zone Glomerulosa

Zone Reticularis

Sinusoids

Zona Fasciculata
Arranged in round to oval
clusters

MMC 2019 – By F ahad . A.

7

Notes Structure

Enclosed by a thin layer of connective tissue. Capsule
Cross -sections are seen in the capsule. Nerves
Penetrate the capsule and branch into sinusoids that
supply the cortex and medulla.
Blood Vessels
Cells that synthesize and secrete steroid hormones.
- Zona Glomerulosa - outer zone (15%) of glomerular -like
clusters of cells that secrete aldosterone. The cells have a
central nucl eus and lipid filled ("foamy") cytoplasm
- Zona Fasciculata - middle zone (80%) of two -cell wide
vertical cords that secrete cortisol. The cells have a central
nucleus and lipid filled ("foamy") cytoplasm
- Zona Reticularis - inner zone (7%) of one -cell wide
anastomosing rows that secrete precursors of testosterone.
The cells have a central nucleus and eosinophilic cytoplasm

Cortex

Chromaffin Cells - modified postganglionic sympathetic
neurons that secrete catecholamines (epinephrine or
norepinephrine)
Ganglion Cells - infrequent sympathetic ganglion cells

Medulla

Sinusoidal capillaries (or sinusoids) are one type with a
larger diameter (15 to 30 µm) and more irregularly shaped.
sinusoids

Adrenal gland on histologyguide.com

155a + MHS 216 MH VS Code – Histologyguide.com

MMC 2019 – By F ahad . A.

8

4 – Pituitary gland

Posterior Pituitary
Anterior Pituitary
تسمى ايضا
Adenohypophysis
تسمى ايضا
Neur ohypophysis
تسمى ايضا
Pars Nervosa
comprises most of the - Pars Distalis : (1)
anterior lobe (~75%) and contains five
types of endocrine cells.
1- Chromophobes %50
2- Acidophils %40
3- Basophils %10
not shown. -: Tuberalis Pars (2)

thin remnant (<2%) -: Pars Intermedia) 3(

at interface between the anterior and
posterior lobes that contains numerous
colloid (protein) -filled cysts .

Acidophils

Basophils
Chromophobes

s Sinusoid

تعمل على استقبال الهرمونات من
كال Acidophils + Basophils

Colloid

" cysts Rathke's "

MMC 2019 – By F ahad . A.

9

تكملة - Posterior Pituitary

Pituicytes Herring Bodies

MMC 2019 – By F ahad . A.

11

The pituitary gland is composed of an anterior and posterior lobes.

Notes Structure
 Contains three divisions: -
1) Pars Distalis - comprises most of the anterior lobe (~75%)
and contains five types of endocrine cells.
 a) Chromophils - stain with H&E and secrete hormones
b) Acidophils - stain pinkish -red with H&E .
c) Basophils - stain bluish -purple with H&E .
d) Chromophobes stain po orly with H&E and do not secrete
hormones.
e) Sinusoidal Capillaries - extensive network that receives
hormones from acidophils and basophils .

2) Pars Tuberalis

3) Pars Intermedia - thin remnant (< 2%) at interface between the
anterior and posterior lobes that contains numerous colloid
(protein) -filled cysts

Anterior

Pituitary
Axons from the hypothalamus that release hormones into the
capillaries of the pars nervosa.

1) Pituicytes - most nuclei belong to glial cells.

2) Herring Bodies - dilations of axons filled with neuro -secretion
vesicles.

Posterior

Pituitary

Pituitary gland on histologyguide.com

149 MH VS Code – Histologyguide.com

MMC 2019 – By F ahad . A.

11

Examine the VS slide MHS 209 to recognize the relation between Thyroid, parathyroid

and thymus .

Task: With the help of a diagram summarize the effect of the hypothalamus / pituitary

complex on the rest of the body i.e. hormones secreted and their action on target
organs and tissues .

MMC 2019 – By F ahad . A.

12

List all the hormones secreted by the pituitary gland


رفعت المحاضرة من قبل: Fahad Ahmed
المشاهدات: لقد قام 6 أعضاء و 28 زائراً بقراءة هذه المحاضرة






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