د.زياد

Immunopathology

HYPERSENSITIVITY REACTIONS

Urticaria

Angioedema

Graves disease

Immune-complex-mediated vasculitis

Lupus: butterfly rash

Maculopapular Rash

Yellow discoloration + Dermatitis

Cholestasis

Immunodeficiency syndrome

AIDS Pneumocystis carinii

PCP

CMV inclusions

Mycobacterium tuberculosis infection of lung is shown here with numerous red rods seen with acid fast staining.

Candida infections

Kaposi's sarcoma

Autoimmunity

Examples of Organ Specific
Lungs of a patient with Goodpasture’s Vitiligo
Hashimoto’s disease (thyroiditis)

Butterfly Rash in SLE

LE Cell

SLE, SKIN

SLE, GLOMERULUS


Libman-Sacks vegetations, also called Libman-Sacks endocarditis, are on BOTH sides of the leaflet.

Glomerulus with thickened pink capillary loops in a patient with lupus nephritis

The periarteriolar fibrosis ("onion skinning") seen in the spleen in patients with SLE

Here is a glomerulus in which the capillary loops are markedly pink and thickened such that capillary lumens are hard to see. This is lupus nephritis.

EM; Amyloid

"apple-green" birefringence In polarized light + Congo red


Kidney Amyloid deposited primarily in the glomeruli, lead to thickening of the mesengial matrix with widening of the basement membrane, it also deposited in the peritubular tissue, arteries & arterioles

Spleen splenic follicles …….Sago spleen. red pulp …………….Lardaceous spleen

Diagnosis Site of biopsy:kidney, gingival, rectum, skin, or omental fat Stains:H&E, Congo red, Iodine, … Confirmation can be obtained by Electron microscopy, non-branching fibrils of indefinite length and a diameter of approximately 7.5 - 10 nm.