Antibiotic

Clindamycin

Presented byProfessor Dr. Imad A-J Thanoon

Clindamycin

Mechanism of action

Pharmacokinetics

May be given Orally or parenterally Orally: Rapidly absorbed. Bioavailability is 90%. Widely concentrated in tissues including bones, and body fluids. It diffuses across the placenta. Metabolized in liver Excretion- urine and bile

Antibacterial activity

Susceptible bacteria

Medical use

Bacteremia Bacterial Endocarditis Prophylaxis Deep Neck Infection Intraabdominal Infection Joint Infection Malaria Osteomyelitis Pelvic Inflammatory Disease Peritonitis Pneumonia Aspiration Pneumonia Sinusitis Skin or Soft Tissue Infection Surgical Prophylaxis Toxoplasmosis - Prophylaxis Toxoplasmosis Bacterial Infection

adverse drug reactions

Common adverse drug reactions associated with systemic clindamycin therapy — found in over 1% of people — include: diarrhea, pseudomembranous colitis ,nausea , vomiting, abdominal pain or cramps and/or rash.High doses (both intravenous and oral) may cause a metallic taste. Common adverse drug reactions associated with topical formulations - found in over 10% of people - include: dryness, burning, itching of skin.Hepatotoxicity & bone marrow suppression- rare

Clindamycin and dentistry

Why clindamycin
Clindamycin is a highly effective drug when used to fight dental infections. The reason is that Clindamycin is nearly completely absorbed (90%), and penetrates deeply into the soft tissues of the body, as well as bone, where dental infections reside.