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SALMONELLA

Under the current American CDC (Center for Disease Control) classification scheme there are two species: Salmonella enterica and Salmonella bongori. S. enterica is further divided into 6 subspecies.
Classification


S. enterica contains more than 2500 serotypes (2541 in l 2004) differentiated on the O and H- Antigens Salmonella serotype (serovar) Typhimurium, Salmonella serotype Enteritidis, Salmonella serotype Typhi, Salmonella serotype Paratyphi, Salmonella serotype Cholerae suis etc. Ex.: Salmonella enterica subspecies enterica serovar Typhi or Salmonella Typhi


Although the classification of salmonellae relies primarily on serotyping of surface antigens, the typhi serotype can be differentiated from other serotypes on the basis of its relatively inert biochemical behavior. The typhi serotype is negative for Simmons citrate, gas from glucose, acetate utilization, etc.

Morphology

Gram – negative rodsuncapsulated (except S. typhi)Unsporulated.Peritrichous flagella (ensure motility)

Cultural properties

Aerobe-anaerobe facultativeGrow easily on simple culture mediaOnto selective and differential media that contain biliary salts and lactose grow like lactose-negative “S” colonies.produce de H2S.



Biochemical properties
Motile, Lactose negative. acid and gas from glucose, mannitol, maltose, and sorbitol. Indole test negative Methyl red test positive Voges-Proskauer test negative. Citrate positive (growth on Simmon's citrate agar) Lysine decarboxylase positive Urease negative H2S produced from thiosulfate Phenylalanine and tryptophan deaminase negative Gelatin hydrolysis negative

TSI (Triple Sugar Iron) MIU (Motility Indole Urea). Simmons Citrate medium

Epidemiology:
In many countries Salmonella enteritis is the third most commonly reported form of “food poisoning”. The infection is zoonotic, and the poultry is the source of infection. Other sources of infection include milk products, food and water contaminated with animal feces or urine

(1) Enteritis

8-48 hours after the ingestion of food or drink contaminated with Salmonella, enterocolitis begins with nausea, vomiting, abdominal pain, diarrhea which can vary from mild to severe. In some cases manifestation include fever, headache and chills. Salmonella enteritis last about 5 days, but severe loss of fluids and electrolytes may be lifethreatening in infants and elderly patients.

(2) Enteric fever (typhoid)

About 7-14 days after ingesting salmonellae, patients begin to develop symptoms and signs of typhoid, including anorexia, headache, abdominal pain, fever up to 40 C,

Diagnosis

The diagnosis of salmonellosis requires bacteriologic isolation of the organisms from appropriate clinical specimens. Laboratory identification of the genus Salmonella is done by biochemical tests; the serologic type is confirmed by serologic testing. Feces, blood, or other specimens should be plated on several nonselective and selective agar media (blood, MacConkey, eosin-methylene blue, bismuth sulfite, Salmonella-Shigella, Hektoen agars).

Treatment of salmonella




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