Breast

Normal breast tissue: Note the duct, lobules and fibrofatty stroma

Myoepitheial cells, around ductal epithelium , stained for actin


fibrocystic changes of the breast, adenosis, fibrosis, cystic dilatation +/- apocrine changes


Fibrocystic changes with Apocrine change (large tall cells with granular eosinophilic cytoplasm) fibrosis, cystic dilatation

fibrocystic changes of the breast, adenosis, fibrosis, cystic dilatation &apocrine changes

Adenosis, back to back glands with little stroma


Epithelial hyperplasia: Increase number of lining epithelium of ducts and /or lobles: Mild hyperplasia

moderate hyperplasia

Atypical hyperplasia

Dr. Nazar Jawhar- Department of Pathology

Fibroadenoma of breast-The mass is well-circumscribed. Grossly it is firm and rubbery. With yellow tan nodular cut surface.

This fibroadenoma has compressed ducts surrounded by fibrous stroma .

This fibroadenoma has compressed ducts surrounded by fibrous stroma .


In situ carcinoma: The ducts (or lobules) are filled with atypical cells, having varies histological architecture and all are limited by the basement memebrane of the ducts

Dr. Nazar Jawhar- Department of Pathology

In situ carcinoma: The ducts (or lobules) are filled with atypical cells, having varies histological architecture and all are limited by the basement memebrane of the ducts Solid and cribriform patterns.

Dr. Nazar Jawhar- Department of Pathology

Comedo ductal carcinoma in situ: The ducts filled with atypical cells, the central part show coagulative necrosis. This is a high grade type of DCIS


Paget's disease of the breast . Note the overlying hyperkeratosis of the skin with eczemal like lesion.


Paget's disease of the breast . The large cells infiltrating into the epidermis represent intraepithelial extension of an underlying ductal carcinoma in situ or invasive ductal carcinoma.


Invasive breast carcinoma: irregular firm to hard mass, whitish greyish, ill-defined borders


Invasive breast carcinoma: irregular firm to hard mass, whitish greyish, ill-defined borders


Infiltrative ductal carcinoma, irregular glandular & trabecullar pattern surrounded by desmplasia & infiltrating nerve fiber


About 5 to 10% of breast cancers are of infiltrative lobular carcinoma. There is about a 20% chance that the opposite breast will also be involved, and many of them arise multicentrically in the same breast. The cells show indian file pattern (rows of cells)