Blood Physiology Lec. 5
Dr. Basim A. Al-Ka’abi
MBChB (Medicine)
MSc, PhD (Medical Physiology)
Anemia:
• Definition
• Main classifications
Iron deficiency anemia:
• Iron loss, causes
• “Myeloperoxidase”
• “Hypochromic microcytic anemia”
Megaloblastic anemia:
• B
12
and folate deficiency
• “Macrocytic normochromic anemia”
Blood loss anemia:
• Acute blood loss
• Chronic blood loss
Hemolytic anemias:
• “Shortened” red cell life span
Classification of HAs:
• Intracorpuscular defects
• Extracorpuscular defects
Hereditary spherocytosis:
• Definition, “spectrin”
• Loss of surface area
• Ruptured on passing through spleen
G6PD deficiency:
• Definition
• Fava beans, legumes
• Certain drugs
Sickle cell anemia:
• Abnormal Hb, “HbS”
• “Crystal” precipitation under low O
2
tension
• “Sickle” appearance, highly fragile
Thalassemia:
• “Mediterranean” anemia
• Inadequate synthesis of alpha or beta globin chains
• Hypochromic microcytic anemia
Good Luck