Procedure
2 students acts as volunteers
PR and Bp recorded for each volunteer
Exercise for 5 min.
PR and Bp recorded immediately following exercise and after 3 min.
One student take 40 mg propranolol, other take placebo
Again record resting and exercise PR & Bp
Table of results
After treatment
30 min
Before treatment
3 min after
After exercise
rest
3 min after
After exercise
rest
PR
Bp
Propranolol
Prototype Drug
Trade name (( Inderal ))
Non-selective
Lipid soluble (cross BBB)
Low bioavailability (extensive 1st. P. E.)
T1\2 = 3 - 6 hr.
Pharmacological effects
Cardiac effects :Negative inotropic effectsNegative chronotropic effects.↓ Cardiac output (COP) and O2 consumption↓ S-A and A-V conduction velocityAll effects are mostly due to β1 blockade & more pronounced during exercise
Pharmacological effects
Vascular effects :Prevents β2-mediated vasodilatationHypotension triggers a reflex peripheral vasoconstriction.
Pharmacological effects
Antihypertensive effects :
Reduction in COP
Reduction of renin release from the juxtaglomerular cells of the kidney
Presynaptic inhibition (reducing ND release)
TPR
Pharmacological effects
Disturbances in glucose metabolism:↓Glycogenolysis↓Gluconeogenesispropranolol can cause exercise-induced hypoglycemiapropranolol can mask the symptoms of hypoglycemia
Clinical Uses
CVSAngina pectoris: !Myocardial infarction: !Dysrhythmias : Heart failure : !!Hypertension :
Clinical Uses
Thyrotoxicosis
Migraine prophylaxis
Benign essential tremor
Anxiety
Adverse effects
Bronchoconstriction
Bradycardia
Arrhythmias. (rebound tachycardia)
Cardiac depression
Hypoglycemia
Fatigue
Cold extremities
Sexual impairment
Nightmares
Contraindications
asthma and other bronchospastic conditions,
severe bradycardia
atrioventricular blockade
severe unstable left ventricular failure.
Diabetes
