Female Genital System

Markedly distorted uterine corpus with multiple irregular masses protruding from its surface. These are subserosal leiomyomata.
Leiomyomas uteri
The uterus has been opened revealing several large masses that protrude from under the endometrial mucosa (submucosal). There are also intramural and subserosal examples. One of the submucosal tumor is in the form of pedunculated polyp that has protruded through the cervix

Leiomyoma uterus gross

Multiple uterine leiomyomas.


Smooth muscle tumors of the uterus are often multiple. Seen here are submucosal, intramural, and subserosal leiomyomata of the uterus.
Uterus, leiomyomata

Leiomyoma uterus gross

Leiomyoma uteri
Here is the microscopic appearance of a benign leiomyoma. Normal myometrium is at the left, and the neoplasm is well-differentiated so that the leiomyoma at the right hardly appears different. Bundles of smooth muscle are interlacing in the tumor mass.

Leiomyoma uteri

Leiomyosarcoma uterus gross

The tumor forms a large , irregular intramural and submucous mass. There are foci of hemorrhage (red) and necrosis( yellow).


This is a leiomyosarcoma protruding from myometrium into the endometrial cavity of this uterus that has been opened sagittally so that the halves of the cervix appear at up and down. Fallopian tubes and ovaries project from both sides. The irregular nature of this mass suggests that is not just an ordinary leiomyoma.
Uterus, leiomyosarcoma, G


The tumor is much more cellular and the cells have much more pleomorphism and hyperchromatism than the benign leiomyoma. An irregular mitosis is seen in the center.
Leiomyosarcoma


As with sarcomas in general, leiomyosarcomas have spindle cells. Several mitoses are seen here, just in this one high power field.
Leiomyosarcoma

Endometrial polyp

Huge endometrial polyp filling the endometrial cavity. There is also a smaller endocervical polyp and a subserosal leiomyoma.
The uterus has been opened anteriorly through cervix and into the endometrial cavity. High in the fundus and projecting into the endometrial cavity is a small endometrial polyp. Such benign polyps may cause uterine bleeding.



Cystically dilated glands and a fibrous stroma with thick-walled vessels.
Endometrial polyp LP mic

The tumor shown is polypoid (exophytic)

Endometrial adenocarcinoma
The tumor shown is extensive, nodular & highly infiltrating.

Endometrial adenocarcinoma

A mass with foci of hemorrhage within the uterine corpus consistent with a fungating endometrial adenocarcinoma


A, Endometrioid type, infiltrating myometrium and displaying cribriform architecture. B, Higher magnification reveals loss of polarity and nuclear atypia.
Endometrioid adenocarcinoma


The endometrial glands are very crowded, adopting a back-to-back arrangement; these glands are very complex with a gland within gland pattern. The lining consists of cells with pseudostratification and disorganization
Endometrioid carcinoma



Moderately-differentiated endometrioid adenocarcinoma

Poorly-differentiated endometrioid adenocarcinoma

Endometrial adenocarcinoma of endometrioid type with acomponent of squamous carcinoma (arrow). In contrast to the previous figure, the squamous component has markedly atypical cytologic features.
Adenosquamous ca


C, displaying formation of papillae and marked cytologic atypia. D, Immunohistochemical stain for p53 reveals accumulation of mutant p53 in serous carcinoma.
Serous carcinoma of the endometrium