Female Genital System

Paget's disease of vulva in 87-year-old woman. Disease involves labia majora and labia minora. Note clinical similarity to leukoplakia.
Paget disease of the vulva

There are scattered large, clear tumor cells within the squamous epithelium

Paget disease of the vulva

The cancer was treated by radical vulvectomy. Squamous cell carcinoma of the vulva usually occurs in older women, or as a complication of HPV infection in younger women.
Exophytic SCC vulva arising from Rt. labium minus.

Variably sized, invasive, squamous nests some with central keratinization.

Well-differentiated SCC of vulva

The grape-like configuration of this lesion is characteristic.

Sarcoma botrryoides (embryonal rhabdomyosarcoma) of vagina