Gastrointestinal Tract

Gross appearance of gastric polyps of hyperplastic type. Many of the lesions show central umbilication.
Low-power microscopic view of gastric polyps of hyperplastic type. The cystic dilatation of the glands is more evident on the left side.
Hyperplastic polyp stomach

Hyperplastic polypPolyps are due to proliferation of foveolar cells.

The adenoma is composed of dysplastic epithelial cells with a high risk for progression into malignancy.
Gastric adenomatous polyp (adenoma)

Diagram of growth patterns and spread of gastric carcinoma

In early gastric carcinoma (A), the tumor is confined to the mucosa and submucosa and may exhibit an exophytic, flat or depressed, or excavated conformation. Advanced gastric carcinoma (B) extends into the muscularis propria and beyond. Linitis plastica is an extreme form of flat or depressed advanced gastric carcinoma.
Early
Advanced

d
Polypoid (Fungating, exophytic) adenocarcinoma of the stomach

Adenocarcinoma-ulcerative (excavating)

Ulcerative carcinoma may closely mimic chronic peptic ulcers. However, in advanced cases, there are heaped-up, beaded margins and necrotic bases. The neoplastic tissue extends into the surrounding mucosa and wall; this leads to flattening of the mucosa surrounding the ulcer.

The wall of the stomach is thickened and rubbery hard due to an extensive infiltration with diffuse type carcinoma: signet ring cells.
Linitis plastic/diffuse type carcinoma

Adenocarcinoma-intestinal type

Diffuse-type carcinoma showing signet ring cells

Gastric carcinoma intestinal Vs diffuse

Gastric carcinoma. A, Intestinal type demonstrating gland formation by malignant cells, which are invading the muscular wall of the stomach. B, Diffuse type demonstrating signet-ring carcinoma cells.

Virchows Node Metastases from gastric carcinoma can spread to the left supraclavicular area.

Scattered duct structures were seen in the dermis.

Sister Mary Joseph nodule



Typical gross appearance of Krukenberg tumors of ovary. The involvement is bilateral and the tumors are characterized by a multinodular outer appearance.
Krukenberg tumors ovary
The multinodular quality of the ovarian metastasis is typical of Krukenberg tumor. A case of metastatic lobular ca breast