Hematopathology

Peripheral blood smear

• Normal blood leucocytes morphology

Neutrophil

Lymphocyte

Skin infection Respiratory infection

Neutropenia;
Fever and Infections due to reduced immunity, especially;






(Ecchymosis)

Thrombocytopenia;

Bleeding manifestations into the skin;

( Petechiae)

• Organ and Tissue Infiltration by the leukemic cells:Splenomegaly..Hepatomegaly..Bone pain..Arthralgia..
Facial Palsy
Lymphadenopathy

Ant. chamber infiltration

Ocular infiltration

Tongue infiltration

Gum infiltration

Skin infiltration

Nodular lesion

Raised erythematous lesion

ALL (Lymphoblasts)
The WBC's seen here are lymphocytes, but they are blasts--very immature cells with larger nuclei that contain nucleoli. Such lymphocytes are indicative of acute lymphocytic leukemia (ALL

AML (Myeloblasts)

Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is a linear red "Auer rod" composed of crystallized granules. These findings are typical for acute myelogenous leukemia (AML)

AML (Myeloblast with Auer rod)

Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is a linear red "Auer rod" composed of crystallized granules. These findings are typical for acute myelogenous leukemia (AML)

Cytochemistry in AML M1 – M4

SBB positive

PAS negative