Carcinomatous tissue is seen on the posterior aspect (lower left). Note the solid whiter tissue of cancer in contrast to the spongy appearance of the benign peripheral zone on the contralateral side.
Adenocarcinoma of the prostate
Extensive tumor appearing as an irregularly shaped, yellowish mass in a gland that is also involved by nodular hyperplasia.
Adenocarcinoma of the prostate
Prostatic adenocarcinoma
These sections through a prostate removed via radical prostatectomy reveal irregular yellowish nodules, mostly in the posterior portion. This proved to be prostatic adenocarcinoma. Prostate glands containing adenocarcinoma are not necessarily enlarged.A, Photomicrograph of a small focus of adenocarcinoma of the prostate demonstrating small glands crowded in between larger benign glands. B, Higher magnification shows several small malignant glands with enlarged nuclei, prominent nucleoli, and dark cytoplasm.
Prostatic adenocarcinoma
Prostatic adenocarcinoma initially presenting as left supraclavicular lymphadenopathy.
Prostatic adenocarcinoma lymph node metastasisProstatic adenocarcinoma back to back glands
At high magnification, the neoplastic glands of prostatic adenocarcinoma are still recognizable as glands, but there is no intervening stroma and the nuclei are hyperchromatic.
Prominent cytoplasmic vacuolation in prostatic carcinoma as a result of hormonal treatment. The vacuolization is also present in the area of perineurial invasion.
Prostatic adenocarcinoma perineurial invasion & effects of hormonal treatment
The presence of prostatic glands within perineural spaces is common in these tumors. This finding is a strong indicator of malignancy but is not pathognomonic. It does not represent permeation of perineurial lymphatic vessels, as formerly believed, but rather spread of glandular tissue along planes of lesser resistance. Its presence in a needle biopsy specimen is a good predictor of capsular invasion by the tumor.