The nodules occur mainly in the lateral lobes. Such an enlarged prostate can obstruct urinary outflow from the bladder and lead to an obstructive uropathy.
Benign prostatic hyperplasia (BPH)
There are well-defined nodules that compress the urethra (arrowheads) into a slitlike lumen.
Nodular prostatic hyperplasia
Enlarged lateral lobes and median lobe that obstructs the prostatic urethra. This led to obstruction with bladder hypertrophy, as evidenced by the prominent trabeculation of the mucosal surface. Obstruction with stasis also led to the formation of the yellow-brown stone (arrow).
Nodular prostatic hyperplasia
Median lobe
Lateral lobes
A, Low-power photomicrograph demonstrates a well-demarcated nodule at the top of the field, populated by hyperplastic glands. In other cases of nodular hyperplasia, the nodularity is caused predominantly by stromal, rather than glandular, proliferation.
Prostatic nodular hyperplasia
B, Higher power photomicrograph demonstrates the morphology of the hyperplastic glands, with the characteristic dual cell population: the inner columnar secretory cells, and the outer flattened basal cell layer.
The hyperplasia can involve both glands and stroma, though the former is usually more prominent. Here, a large hyperplastic nodule of glands is seen.
Benign prostatic hyperplasia (BPH)