Osteitis fibrosa
Historical example of extreme osteitis fibrosa cystica. Note deformity of bone with numerous cysts and brown tumors.Osteitis fibrosa
Cystic changes and cortical alterations in bones of hands of patient with functioning parathyroid adenoma.Dramatic change evident 9 months after removal of adenoma.
Extensive changes in bones of pelvis and femur caused by functioning parathyroid adenoma.
Osteitis fibrosaSame pelvis and femur 8 years after removal of adenoma. Note complete reversion to normal.
Bone changes in hyperparathyroidism. There is marked resorption of bone trabeculae and clustering of osteoclasts.
Osteitis fibrosa bone
Here is a "brown tumor" of bone in a patient with hyperpara-thyroidism. The high parathormone levels increase osteoclast activity and produce irregular bone resorbtion with microfractures and hemorrhage and macrophage proliferation and fibrous connective tissue proliferation.
The center of the "brown tumor" contains osteoclasts, mononuclear cells and fibroblasts with focal hemorrhages. The hemosiderin from the hemorrhage produces the grossly brown color. Such lesions are nowadays uncommon because hyperparathyroidism is treated before such lesions develop.
Osteitis fibrosa /brown tumor/ hyperparathyroidism