Lt., longitudinal slice of a tibia from a case of Paget disease, showing the marked thickening of the cortical bone. The bone is thick, but softer than normal bone. As a result there is anterior bowing of the tibia, and the bones are more liable to fracture than are normal bone. Rt., Paget disease of the skull. Note the gross thickening of the diploe of the skull. The bone is extremely vascular. This vascularity sometimes results in cardiac failure in patients with Paget disease.
Paget disease of bone
Mosaic pattern of lamellar bone pathognomonic of Paget disease.
Paget disease of boneRt., the sliced femur shows thickening of the cortical bone. An osteogenic sarcoma has arisen at the distal end of the bone (arrow). Osteogenic sarcoma is a well recognized complication of Paget disease. There are two age peaks for osteogenic sarcoma, one in adolescents and young adults, and the second in older people with Paget disease. Lt., Paget disease of the skull complicated by the development of an osteogenic sarcoma (arrow).
Paget disease of bone