Sarcoidosis lung
Rt. Low power: non caseating granulomas are present in the lung parenchyma. The inciting agent for this granulomatous disease is unknown - speculation ranges from an unidentified microorganism to tree pollen!. Sarcoidosis typically presents with non-caseating granulomas. Lt. Medium power: there is interstitial non-caseating granulomatous inflammation. Giant cells and histiocytes form nodular aggregates without necrosisHigh power: characteristic sarcoid noncaseating granulomas in lung with many giant cells.
SarcoidosisEach of the two multinucleated giant cells shown here has an asteroid body with surrounding vacuoles in the cytoplasm. The basophilic body in the giant cell to the left may be an early, small Schaumann body.
Sarcoidosis lymph node
Multiple noncaseating epithelioid granulomas There is no caseation, but some contain calcified laminated Schaumann bodies (arrows).