3
rd
-year class
Practical Pharmacology
2010-2011
Lab.4
Problem solving(pharmacokinetics)
Problem No.1
The maximum oral dose for propranolol in
treatment of hypertension may be up to 320
mg per day(in 3 divided doses),while the
maximum intravenous dose of the same drug
is only 10 mg for the treatment of cardiac
arrhythmias.(
Discuss
)
Problem No.2
A patient on warfarin for the treatment of deep
venous thrombosis (DVT) developed bleeding
per rectum after receiving therapeutic doses
of indomethacin (NSAIDs) for severe pain in
the inflamed lower limb.(
Discuss
)
Problem No.3
A 20 years old epileptic female patient has been
well controlled on carbamazepine tablet;200
mg twice daily. She developed
dizziness,diplopia and ataxia following
prescription of erythromycin for
tonslitis.(
Discuss
)
Problem No.4
A patient with severe renal impairment, his
doctor prescribed for him gentamycin 40 mg
three times daily for treatment of urinary tract
infection. The nurse, by mistake, gave him an
ampoule of 80 mg three times daily. He
developed deafness.
What is the possible
explanation?
Problem No.5
A 60 years old patient was diagnosed to have
angina pectoris. He was put on propranolol 40
mg three time daily for the last six months .
He traveled to the north of Iraq ,but forgot to
take his propranolol tablets with him. After
one day of stopping his treatment , he
experienced exacerbation of his anginal
attacks which were worse than his attack
before treatment.(
Discuss
)