gestational diabetes

Gestational diabetes

metabolic disease result from underproduction of insulin which effect CHO , fat &protein metabolism During pregnancy 1.preexisting 2.gestational


Homeostasis during pregnancy NP - FBS maintained 4-5 mmol/l -insulin level double to maintained in the 2-3rd trimisters - preg is insulin resistant state -causes of resistant a. placental hormones b. changes in periphrel insulin receptors Glucose cross the placenta by facilitated diffusion

Gestational Diabetes State of glucose intolerance which occurs at the end of second trimester or early third trimester met WHO criteria for diabetes and revert to normal after peurperium Incidence : 1 : 1000 _ 1 : 2000

WHO criteria fasting 2hr postprandial Diabetic >=8mmol >=11mmol \ L Normal <8mmol <11mmol \ L

Screening for diabetes

No single test has been shown to be perfect GTT high risk or potential diabetic - h\o 1 st degree relative or 2 nd -poor obstetrical history -glycoseuria on two occasion first in the morning -polyhydramnias -macrosomic infant -obese mother -advance maternal age GTT on low risk group cannot be justified


Glucose challenge testHbA1CGlycosylated proteinGlucoseuriaStandard meal testEffect of diabetes on pregnancyFeta & neonatal complication miscarriage2nd trim. Fetal death congenital fetal abnormalities – 3 timesPIHFetal macrocosmicUnexplained still birth Polyhydramnia & preterm labour

Neonatal : hypoglycemia , polycythemia , hyperbilirubinemia RDS birth asphyxia & trauma hypocalceamia&magnesemia Maternal mortality &morbidity mm improved after insuline -nephropathy -retinopathy -PE -Infection :UTI , moniliasis ,chest infection Sever hypo & hyperglycemia -operative delivery : 50%


Effect of pregnancy on diabetes Difficulty in control lower renal threshold diminish sensitivity to insulin as pregnancy advance Nephropathy Retinopathy previous proliferative retinopathy was contraindication for pregnancy

Management

Required diabetic team Strict metabolic control before and during pregnancy Increase frequency of ANC visit To achieve euglycemia -Diet 1800 calories should be prescribe i.e30-35kcl \kg if ideal body weight + 300kcl to anticipate wt gain during pregnancy -50-60 % CHO complex -18-20% as protein -25% as fat ( important to have bed time snaks )

Insulin

Oral hypoglycemic ………not recommended -better to use combination -Short acting +intermediate in two divided dose -long acting rarely usedSpecial formula to calculate insulin requirment: unit insulin = Bwt Ч0.6 1st trimester = 0.7 2nd = 0.8 3rd

Dosage schedule

-Serum alfa fetoprotein -maternal : renal ,cardiac , ophthalmic ,function are monitor - glycosylated ( hba1c) monthly Timing of delivery -maternal state is stable Blood glucose level is euglycemic Fetal growth is satisfactory Wait until term (38-40wks ) not beyond, if condition not met so intervention


Intrapartum Need to keep the mother euglycemic in labour Continues infusion 5%- 10% dextrose + 0.5-2 unit of insulin Measure blood glucose every 2hrs ,adjust insulin accordingly aim is to keep level 80-100mg/dl Fetal scalp electrode Aim is vaginal delivery unless there is obstetrical complications c/s rate 50%


Postpartum After delivery of placenta insulin requirment drops sharply 1st 48hrs most pt do not require insulin After depend on sliding scale Encourage breast feeding with addition of 70 calories Counsel about contraception barrier better combine pills risky progesterone only pills failure rate IUCD infection sterilization with advance vascular involvment