This transplant kidney removed from the recipient is swollen and
has global infarction from acute rejection.
Acute Rejection: Renal Transplantation
The glomerulus is normal, but the tubules are infiltrated by many
lymphocytes. The immunofluorescence pattern shows immune deposits
between glomeruli in the interstitium. Both type II and type IV immune
hypersensitivity reactions contribute to this rejection reaction.
Acute Rejection: Renal Transplantation
A renal biopsy that
demonstrates marked
interstitial fibrosis in a
patient with chronic
vascular rejection
The renal arteries with
chronic vascular
rejection are markedly
thickened and fibrotic.
There is interstitial
fibrosis and chronic
inflammation
Chronic Rejection: Renal Transplantation