hematology

Aplastic anaemia

Aplastic Anaemia
Definition:
Pancytopenia resulting from aplasia of the B.M, classified into primary and secondary types.

Pancytopenia: Reduction in the blood count of all major cell lines (RBCs, WBCs and Plts)

Pathogenesis
Reduction in the number of haemopoietic pluripotential stem cells
and:
A fault in the remaining stem cells
or:
Immune reaction against them

Clinical features

At any age with a peak incidence ~ 30 yrs


Male predominance

Signs and symptoms resulting from anaemia,neutropenia and thrombocytopenia

Laboratory findings
Normochromic, normocytic or macrocytic anaemia
Reticulocytopenia
Leucopenia
Thrombocytopenia
No abnormal cells in P.B
Hypoplasia in the B.M

Diagnosis

B.M sample: distinguish from other causes of pancytopenia